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It made him question things that he had learned and university and led him to start looking for alternatives that could restore immune systems and health without side effects. Ultimately, after quite a few years and a lot of research, he decided to open a free of charge clinic in Denmark.
The main idea behind the clinic was to begin a debate on natural medicine and to encourage the media to discuss alternative solutions that could save human lives. This led to a huge interest in learning about hemp. And the rest, as they say, is history. Today, Endoca offers a large range of products, and each is produced with certified organic hemp plants that are grown without using any herbicides or pesticides.
They use world-class equipment and cutting-edge testing to ensure that all their products are safe and healthy. Endoca prides itself on creating some of the best CBD products on the market. They are amongst some of the best CBD suppliers in the world, and for good reason.
Here some of the things that we love about Endoca:. While this is generally a good thing, it can result in formulas that lack the full spectrum of cannabinoids for what is often referred to as the entourage effect.
Endoca has been around since the humble beginning of the CBD industry and it really shows in the brand. Each product has a full description, explanation, outline of benefits and instruction on how to use it.
Endoca is best known for their CBD oil. They offer both raw hemp oil drops and CBD hemp oil drops in strengths of either mg or mg. The main difference between hemp oil and raw hemp oil is that raw hemp oil is filtered and gently heated to transform CBDa into CBD. Raw hemp oil is, of course, not heated or filtered during the production process, so the CBDa is left intact. Raw hemp oil maintains the full spectrum of the cannabinoids, terpenes, and flavonoids from the original plant, and is thought to be a useful addition to a raw food diet.
There are approximately drops per bottle, and a single drop contains about 5 mg of CBD. Each bottle of oil is vegan, gluten-free and non-GMO. The CBD capsules are also available as either raw hemp oil or just hemp oil, and come in strengths of either mg or mg. Since most people react differently to CBD, newbies will usually start with a low dose. While CBD capsules are convenient to use on-the-go, the raw hemp oil capsules need to be stored in the fridge.
The most popular of the Endoca edibles is their CBD chewing gum. Fully biodegradable, the Endoca chewing gum is environmentally friendly. Once disposed of, its all-natural components will break down and dissolve, leaving behind nothing but dust. This is a major plus since normal chewing gum poses huge environmental problems. Not only is CBD gum biodegradable in nature, but it can also be beneficial when chewed and even swallowed.
No more hemp smelling breath, or burning throat; only a fresh, minty aroma. Simply slip a box of CBD gum into your bag or pocket — no more worrying about leaking bottles in your bag or having to swallow capsules. Endoca only uses natural flavors from essential oils, meaning that the minty taste of the gum will fade more quickly than the very minty and artificial ones that you may be used to.
Made from organic, food-grade ingredients such as shea butter, vanilla, and coconut oil, the Endoca skin care products are so pure you could eat them. The hemp salve offers a high CBD concentration of mg and provides instant relief from dryness. It can be used on the face and body. The hemp whipped body butter has a very high CBD concentration of mg in a ml container. Other ingredients include; hemp oil, coconut oil, vitamin E, and more. Given the verified quality of the Endoca products, they are reasonably priced.
The company also offers discounts based on buying in higher volumes. The Endoca prices are relatively lower when compared to competitors who sell comparable product lines. The official Endoca website is the best place to buy your products from. This is also where you can find the full Endoca story and how the company was founded. They have one of the best websites in the industry, full of all the information you could possibly need.
There are many theories about pain. However, when it comes to the use of cannabinoids in the management of pain, it is a widely-held observation that its analgesic effects are closely related to the modulation of noradrenaline coming from the brainstem and descending towards the dorsal horn of the spinal cord.
What happens is that these nerve fibers are known to possess GABAergic activity or one that is fully capable of suppressing nerve excitation. When endocannabinoids such as palmitoylethanolamide and anandemide bind to certain receptors in the descending tract of the spinal column, they increase the release of noradrenaline which help attenuate the pain impulses being processed by the noxious sensory neurons found in the dorsal horn. In other words, they block the processing of these pain impulses by flooding it with noradrenaline while also increasing the inhibitory properties of GABAergic fibers.
This can have significant implications in the management of pain in dogs. We mentioned above that cannabidiol has excellent anti-inflammatory effect. This was highlighted in a research that showed CBD to be especially effective in reducing the symptoms of inflammation in acute lung injury. Another study on the same year also established the crucial anti-inflammatory activities of CBD in the management of acute pancreatitis. These 2 studies supported the earlier investigation that suggested CBD as an important adjunct in the management of neuropathic pain and chronic inflammation.
While it is easy to say that these studies were never performed using dogs as test subjects, using laboratory mice instead, the results nevertheless, underscore the increasing importance of cannabidiol in the management of chronic inflammatory disorders. The ability of cannabidiol as a powerful anti-inflammatory is strongly associated with the location of the cannabinoid type 2 CB2 receptors which are mostly found in immune system cells such as monocytes, macrophages, and T- and B- lymphocytes.
Its activity on cytokines help improve the anti-inflammatory action of these immune system cells so that they become very efficient in the management of chronic inflammatory disorders in dogs such as arthritis , inflammatory bowel disorder, canine encephalitis, canine chronic bronchitis, masticatory muscle myositis, acquired myasthenia gravis, and even demodectic mange.
Since one of the cardinal signs of inflammatory processes is the occurrence of pain, the action of cannabidiol on immune system cells can help target two principal problems: There are a lot of reasons why dogs can get nausea or exhibit vomiting. However, it can also be brought about by other reasons such as bacterial infections, foreign body ingestion, acute liver failure, intestinal parasitism, pancreatitis, viral infections, inflammation of the gallbladder, and even as effects of undergoing surgery.
Whatever the case, nausea and vomiting in dogs are almost always characterized by abnormal gastric and intestinal motility. There are three ways in which cannabidiol can help dogs with nausea and vomiting. First, by interacting with CB1 receptors, the endogenous cannabinoids released will help inhibit the firing of cAMP into succeeding neurons.
This helps reduce the number of electrical impulses traveling towards the gut, reducing gastric and intestinal motility. Second, since CB2 receptors are also abundant in the gastrointestinal system, their stimulation can help prevent the activity of the immune system on normal gut flora, allowing for the more efficient digestion and absorption of food molecules which can help minimize nausea and vomiting.
Stimulation of the serotonin receptor has been proven to reduce the sensation of nausea while also suppressing the vomiting reflex. One of the most remarkable areas where cannabidiol preparations are now being used on dogs is in the management of certain types of cancers.
The area has received widespread attention when several promising studies showed the potentially beneficial effects of CBD on cancer treatment. For example, the Boston-based Beth Israel Deaconess Medical Center showed in that cannabidiol has the potential to cause apoptosis or programmed cell death in the neoplastic cells of breast cancer. Madrid-based Complutense University went another avenue studying instead the synergistic qualities of cannabidiol in the enhancement of the cancer cell-killing effects of onco-chemotherapeutic agents.
The study underscored the activity of CBD in hastening the rate upon which the active ingredients of chemotherapeutic agents are absorbed by cancer cells. At the same time the study observed healthy, normal cells were substantially protected because of their reduced exposure to the chemotherapeutic agents. Again, while these studies have been performed in test subjects other than dogs, the implications are nevertheless promising. Since certain breeds of dogs are also more prone in the development of certain types of cancer, adding CBD oil in their diet or even as regular supplementation should protect them against these cancers.
The benefits of CBD oil for dogs should be readily apparent. These can be gleaned both on how they work and the different health conditions upon which these supplements can be used. Generally, these benefits are as follows. Best Carpet Cleaner for Pets.
The inhibitory effect of cannabidiol is one of the most sought-after properties of CBD oil for dogs. Reducing canine anxiety can translate to a variety of benefits for pet parents, too. It allows them the ability to train their dogs properly without causing hyper-excitability or extreme eagerness. Many of the stress- and anxiety- related canine behavioral problems can also be addressed more efficiently. This means your dog will no longer be tearing apart your furniture, upholstery, bedding, carpet, and anything that it can get its jaws on every time it feels anxious.
You need not worry about going after urinary and fecal accidents anymore, saving you the hassle of messy cleanups while keeping the integrity of your belongings.
More importantly, your dog will be calmer, more relaxed, and better equipped to handle frustrations, boredom, and other potential sources of canine anxiety. Best Dog Training Books. With CBD you can help minimize the ill effects of reduced oxygen supply to the brain by helping normalize the firing of nerve impulses from the brain. Do take note that cannabidiol is not a treatment for seizures as this condition can have a variety of causes.
This alone is a benefit that other supplements, let alone medications cannot provide. While it is true that cannabidiol can provide exceptional control of the growth of cancer cells, its cancer-fighting ability is limited only to those types of neoplastic conditions that have already been proven in laboratory settings.
Unfortunately, the list is still short considering that there are hundreds of potential cancers that can hit any breed of dog. Knowing that CBD oil can induce cell death in neoplastic cells while speeding up the rate of uptake of chemotherapeutic agents by cancer cells should provide hope for those pet parents who may have pooches that have certain types of cancers.
It is not a cure for all cancers that are known to affect dogs. But the mere fact that it can play a role in the more effective management of cancers is sure a welcome relief.
Alleviating pain in your dog should help it with its mobility and enjoy its existence to the fullest. They will not be able to tone and strengthen their muscles. In short, their muscles will atrophy or shrink in size and lose their tone. This can lead to other problems.
A dog in pain will also not want to eat which robs it of invaluable nutrients necessary for continued development. It also robs your dog of the much-needed nutrients that can play a role in reducing pain sensation. With CBD oil you can help your dog move as freely as possible by reducing, if not eliminating pain sensation.
Inflammatory disorders are a very common occurrence in dogs. From the gastrointestinal tract to the cardiovascular system to the skin and the respiratory system and a whole lot more, these conditions can also bring discomfort to your beloved pet. And since inflammation is almost always accompanied by pain or discomfort, addressing inflammatory conditions means improving the performance of daily activities of your dog. If the inflammatory disorder happens to be limited to the GIT, then your dog will not be able to receive all the essential nutrients that it needs.
If there is inflammation of the skin your dog will be exposed to secondary bacterial, fungal, or even viral infections because of breaks in the skin secondary to incessant scratching. If the inflammation occurs in the lungs or even in the cardiovascular system, then the issues will be related to oxygenation.
Cannabidiol can help reduce inflammation and free your dog from all of these nuisances. This is one of the most profound benefits of using CBD oil for dogs. As already explained, since cannabinoid type 2 receptors are also found abundantly in immune system peripheral tissues like the spleen, thymus, and tonsils as well as in cytokines that mediate the immune system response, one can expect greater immune system functionality in dogs receiving CBD oil.
In addition to the improvement in the overall immunologic activity of macrophages, B-lymphocytes, and neutrophils, CBD oil also exerts beneficial activity on T-lymphocytes especially immunoglobulin-M levels. This type of immunoglobulin is an unusually large type of immune system cell that is the first to respond to antigenic exposure.
This enhances the immunologic activity of the complement system which further aids in the management of antigen-antibody interactions. What this simply means is that your dog will be more than ready to face any kind of infection that is sent its way.
On hind sight, the improvement in immunologic marking can also play an important role in the identification of hyperplastic cells that have the tendency to mutate and become neoplastic cancer cells.
The neuroprotective capability of CBD oil is directly related to its inhibitory effects on nerve impulse transmission. The generation and propagation of electrical nerve impulses require energy. This can seriously deplete brain cells of glucose and oxygen necessary for other metabolic and physiologic processes. By limiting the firing or discharge of nerve impulses, CBD oil can make the brain and its related structures to go into preservation mode.
This helps relax the brain and its many neurons, allowing them to operate at a more normal pace. The nervous system is an integrative system. All organisms rely on a fully functioning nervous system to coordinate and integrate all other processes in the body so that everything is synchronized.
It is the job of the nervous system that the different functions of the different organs work synergistically together to advance the optimum health and wellness of the entire organism; in this case, your dog.
One of the lesser-known benefits of CBD oil is the promotion of a well-balanced metabolism especially in terms of the more efficient transport of nutrient molecules and the judicious and more sensible storage of energy molecules. Cannabinoid type 2 receptors are known to be present in the gastrointestinal system and this is where energy and metabolic homeostasis or balance actually begins. Endocannabinoids have been established to act on certain tissues that play a role in nutrient transport, metabolism, and energy storage.
As such you can expect these endogenous cannabinoids to be present in the pancreatic islet of Langerhans, the skeletal muscles, the tissues lining the gut, fat cells, and liver cells.
Of particular importance is the ability of endocannabinoids to help modulate insulin sensitivity which, everyone now knows, can play an important role in the development of canine obesity, atherosclerosis, and even diabetes in dogs. Cannabidiol products come in various formulations.
Many come as drop formulations although there are also in tablet or capsule forms as well as sprays and treats. Unfortunately, the addition of synthetic chemicals may adversely affect the safety of the product. Best Dry Dog Food.
We mentioned above that choosing the right CBD oil for your pet can be tricky. As we have already explained above, you really need to be careful when reading the label.
You may also need to check the ingredient list. There are certain parts of the US that are well-regarded as hemp haven. For example, Colorado is well-known for its extensive hemp farms. There are also countries that have been growing premium-quality hemp products through the years.
The two most preferred extraction methods for CBD oil are super-critical CO2 extraction and cold press. These two methods of extraction are considered to be the most appropriate and the safest when it comes to retaining as much cannabidiol from the Cannabis sativa L plant. As you may have already noticed from our list of the best CBD oil for dogs, each product may actually come with an entirely different dosing recommendation. For starters, the dose of CBD oil is quite dependent on the type of formulation that is available.
In our list we presented mostly in oil forms as drops although one is in the form of a spray. Do take note that CBD is also formulated as treats and as capsules. For example, CBD oil drops can be as low as 2 to 4 drops or as high as 20 drops every day.
Capsule preparations will typically come with to milligrams of CBD oil in the form of hemp extracts so your dog can actually take a capsule once or twice a day.
Smaller dogs will definitely require smaller doses of CBD oil. Likewise, larger dogs will require substantially larger amounts of CBD oil. However, there are veterinarians who recommend giving an initial dose of 0.
This can be increased, of course, but should not exceed 1 mg per kilogram per day. The current recommendation is to approach the dosing of CBD oil on a three-tiered method. The idea is to gradually increase the amount of CBD oil being consumed by your dog over a span of several weeks until the maximum desired levels have been reached. Putting your dog on CBD oil supplementation can be tricky. That is why we strongly recommend having a chat with your veterinarian about it so you can be guided accordingly.
The trick is for you to always start with the lowest possible dosage that can guarantee a response from your dog. Give this over a week especially noting for any side effect or untoward reactions.
If none develops you can increase the dose to the next level, again watching out for side effects. We now know that the main action of CBD is in the activation of the endocannabinoid system and stimulation of the serotonergic mechanism. Since these two pathways generally have other physiologic effects, it is possible that CBD oil for dogs can also produce unwanted yet generally tolerable side effects.
Here are some of the more common side effects of CBD oil for dogs. On the plus side of things, CBD oil for dogs is generally regarded as safe and well-tolerated. This is welcome news considering that it belongs to the same plant family as the highly addictive marijuana. On that note, one of the most positive things about cannabidiol is that it will never get your dog high. Cannabidiol or CBD oil for dogs is gaining popularity because of its tremendous benefits to the health of our favorite pets.
Not only is it effective in helping our canine friends alleviate their anxieties and help minimize the effects and severity of seizures, CBD oil for dogs can also boost the immune system, reduce pain and inflammation, protect your dog against certain types of cancer, and protect the nervous system among other things. Check price on Amazon. Contains 3 mg of hemp extract per 10 drops or 0. Contains 5 mg phytochemical-rich PCR hemp oil per 0. Contains 12 mg hemp oil per 1-mL dropper Contains calories and omega-6 and omega- 3 fatty acids 3-ingredient formulation: So why does this matter?
The use of full spectrum hemp extract The use of phytochemical-rich hemp extract The listing of hemp oil in addition hemp seed oil Both full spectrum hemp extract and phytochemical-rich hemp extract signify that most of the plant parts — the stalks, leaves, and flowers — have been used in the extraction process. CB1 Receptors Cannabinoid type 1 CB1 receptors are mostly found in the nervous system, both central and peripheral.
CB2 Receptors Cannabinoid type 2 CB2 receptors are mostly found in the immune system, the gastrointestinal system, and the peripheral nervous system; although recent studies say that CB2 receptors are also found in the brain, albeit in substantially lesser amounts than CB1 receptors.
THC binds directly to the CB1 receptor so that the effects are readily apparent. CBD attaches itself to the receptors rather indirectly in a process many scientists call as modulation. So, how does CBD work? It modulates the activities of cannabinoid receptor types 1 and 2. It stimulates the production of endogenous cannabinoids through activation of the endocannabinoid system.
It stimulates a certain type of serotonin receptor.
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