Learn more about Vitamin D uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Vitamin D. Find patient medical information for Vitamin D3 Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. condition caused by low levels of parathyroid hormone · softening of bones · Prevention of Vitamin D Deficiency · Generalized Changes in Bone associated with. Vitamin D is essential for a vast palette of processes in our bodies. It maintains bone and teeth health, it stimulates all sorts of brain functions.
and Warnings VITAMIN Benefits, Precautions Dosage, Deficiency, D:
Call your doctor for medical advice about side effects. Side effects in more detail. Certain medications can make it harder for your body to absorb vitamin D.
If you take other medications, take them at least 2 hours before or 2 hours after you take Vitamin D3. Other drugs may affect Vitamin D3, including prescription and over-the-counter medicines, vitamins , and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using. Drug Interactions in more detail. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Print this page Add to My Med List. The effects of digitalis and other cardiac glycosides may be accentuated with the oral administration of calcium combined with Vitamin D. Strict medical supervision is needed and, if necessary monitoring of ECG and calcium. Simultaneous treatment with ion exchange resins such as cholestyramine or laxatives such as paraffin oil may reduce the gastrointestinal absorption of vitamin D. The cytotoxic agent actinomycin and imidazole antifungal agents interfere with vitamin D activity by inhibiting the conversion of hydroxyvitamin D to 1,dihydroxyvitamin D by the kidney enzyme, hydroxyvitamin Dhydroxylase.
Studies have shown safe use of doses up to IU during pregnancy although studies in animals have shown reproductive toxicity see section 5. The recommended daily intake for pregnant women in the United Kingdom is IU, however, in women who are considered to be vitamin D deficient a higher dose may be required. During pregnancy women should follow the advice of their medical practitioner as their requirements may vary depending on the severity of their disease and their response to treatment.
Vitamin D and its metabolites are excreted in breast milk. Overdose in infants induced by nursing mothers has not been observed; however, when prescribing additional vitamin D to a breast-fed child the practitioner should consider the dose of any additional vitamin D given to the mother. Fultium-D 3 20, IU Capsules have no influence on the ability to drive and use machines. Adverse reactions are listed below, by system organ class and frequency. Frequencies are defined as: Reporting suspected adverse reactions after authorisation of the medicinal product is important.
Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: The most serious consequence of acute or chronic overdose is hypercalcaemia due to vitamin D toxicity. Symptoms may include nausea, vomiting, polyuria, anorexia, weakness, apathy, thirst and constipation.
Chronic overdoses can lead to vascular and organ calcification as a result of hypercalcaemia. Treatment should consist of stopping all intake of vitamin D and rehydration.
In its biologically active form vitamin D3 stimulates intestinal calcium absorption, incorporation of calcium into the osteoid, and release of calcium from bone tissue. In the small intestine it promotes rapid and delayed calcium uptake. The passive and active transport of phosphate is also stimulated. In the kidney, it inhibits the excretion of calcium and phosphate by promoting tubular resorption. The production of parathyroid hormone PTH in the parathyroids is inhibited directly by the biologically active form of vitamin D3.
PTH secretion is inhibited additionally by the increased calcium uptake in the small intestine under the influence of biologically active vitamin D3.
Vitamin D is well absorbed from the gastro-intestinal tract in the presence of bile. It is hydroxylated in the liver to form hydroxycolecalciferol and then undergoes further hydroxylation in the kidney to form the active metabolite 1, 25 dihydroxycolecalciferol calcitriol. Vitamin D is well known and is a widely used material and has been used in clinical practice for many years. As such toxicity is only likely to occur in chronic overdose conditions where hypercalcaemia could result.
Colecalciferol has been shown to be teratogenic in high doses in animals times the human dose. Offspring from pregnant rabbits treated with high doses of vitamin D had lesions anatomically similar to those of supravalvular aortic stenosis and offspring not showing such changes show vasculotoxicity similar to that of adults following acute vitamin D toxicity.
Fracture prevention with vitamin D supplementation: Effect of four monthly oral vitamin D3 cholecalciferol supplementation on fractures and mortality in men and women living in the community: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.
Prevalence of cardiovascular risk factors and the serum levels of hydroxyvitamin D in the United States: Vitamin D deficiency and risk of cardiovascular disease. Calcium plus vitamin D supplementation and the risk of colorectal cancer [published correction appears in N Engl J Med. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev.
Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging. Vitamin D fortification as public health policy: Eur J Clin Nutr. Prevention of rickets and vitamin D deficiency: Effectiveness and safety of vitamin D in relation to bone health.
Agency for Healthcare Research and Quality; Accessed April 21, Estimation of optimal serum concentrations of hydroxyvitamin D for multiple health outcomes [published corrections appear in Am J Clin Nutr. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents [published correction appears in Pediatrics. Not enough vitamin D: Preventive Services Task Force. Routine vitamin supplementation to prevent cancer and cardiovascular disease: This content is owned by the AAFP.
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Want to use this article elsewhere? Evaluation of the Solitary Pulmonary Nodule. Oct 15, Issue. Recognition and Management of Vitamin D Deficiency. Vitamin D deficiency affects persons of all ages. B 12 , 13 Vitamin D supplementation of to IU per day reduces fractures in older adults. A 16 — 18 To prevent vitamin D deficiency, the recommended intake of vitamin D is IU per day for infants and children with inadequate sun exposure, and to IU per day for adults with inadequate sun exposure.
Risk Factors for Vitamin D Deficiency Age older than 65 years Breastfed exclusively without vitamin D supplementation Dark skin Insufficient sunlight exposure Medication use that alters vitamin D metabolism e. Activation of vitamin D. Activation of Vitamin D Figure 1. Manifestations of Vitamin D Deficiency Bone discomfort or pain often throbbing in low back, pelvis, lower extremities Increased risk of falls and impaired physical function Muscle aches Proximal muscle weakness Symmetric low back pain in women Information from references 1 , 4 , and 8 through Contraindications to Vitamin D Supplementation Granulomatous diseases e.
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News analysis: Health claims about vitamin D examined
However, while adults who are deficient in vitamin D3 do not typically Vitamin D3 passes into breast milk and is therefore not recommended for breastfeeding mothers. In general, side effects from taking vitamin D3 tend to be rare. . all possible uses, directions, precautions, warnings, drug interactions. Vitamin D deficiency happens when your body doesn't get enough of Tell your doctor if you experience any of the following side effects: Q: Is it best to take mg of vitamin C with iu of vitamin D? What is recommended for possible uses, directions, precautions, warnings, drug interactions. Vitamin D is important for the absorption of calcium from the stomach Calcium and vitamin D combination is used to prevent or to treat a calcium deficiency. Do not use in larger or smaller amounts or for longer than recommended. all possible uses, directions, precautions, warnings, drug interactions.